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Highlighted Publication

First structure of an SLC16 family transporter homologue with bound substrate and inhibitor.

Please see our recent publication: Bosshart et al. (2019), Nature Commun.

The Fotiadis Lab

Want to learn about the Fotiadis Lab and its research ?

Please see our publication in International Innovation (2013).

Click here to download the PDF

Eins->Zwei->Drei

Welcome to the website of the Fotiadis Lab

Structure and function of membrane proteins

We investigate the structure and function of membrane proteins with a special focus on membrane transport proteins. The methods of choice are high-resolution microscopy techniques (electron and atomic force microscopy) and X-ray crystallography.

Schematic representation of our working strategies, see Meury et al. (2011), Biol. Chem.

Methods

Our methods of choice for the structure determination of membrane proteins are electron microscopy and X-ray crystallography. In addition atomic force microscopy is used to image membrane proteins embedded in lipid bilayers under near-physiological conditions.

Our mission

Our mission is to assess the structure and function of membrane proteins in the detergent-solubilized state and in their native environment, the lipid bilayer.   

Target proteins

Our target membrane proteins consist mainly of membrane transport proteins and receptors.

Funding

Swiss National Science Foundation (SNSF) Project funding, National Centre in Competence in Research (NCCR) TransCure and NCCR Molecular Systems Engineering, and Sinergia.

Latest Tweets from FotiadisLab @IBMM_UniBE

June 14, 2019:

First structure of an SLC16 solute carrier family transporter with bound L-lactate and inhibitor: www.nature.com/articles/s41467-019-10566-6

Thank you and congratulations Patrick, David and Sara - you did a great job !

February 25, 2019:

Volta phase plate cryo-EM: A first look at the structure of the heterodimeric human amino acid transporter 4F2hc-LAT2 under close to native conditions

Please see the latest publication from the FotiadisLab/NCCR TransCure:
www.ncbi.nlm.nih.gov/pubmed/30795505

February 21, 2019:

New publication of the FotiadisLab within the NCCR Molecular Systems Engineering:
www.ncbi.nlm.nih.gov/pubmed/30705382
Greetings to our collaborators in Basel ! 

December 3, 2018:

New Sinergia Project at the IBMM

The SNSF has granted a Sinergia Project to Dimitrios Fotiadis (UniBE) together with the laboratories of Philippe Plattet (UniBE) and Rainer Riedl (ZHAW) entitled “Morbillivirus cell entry machinery: mechanisms, structures and drug discovery”.

June 18, 2018:

New publication of the FotiadisLab within the NCCR TransCure:
www.ncbi.nlm.nih.gov/pubmed/29558430
Greetings to our collaborators in NYC !

December 6, 2017:

Hüseyin Ilgü from the FotiadisLab and NCCR TransCure receives the Dr. Lutz Zwillenberg-Prize for his excellent Ph.D. thesis at the Dies Academicus 2017 of the University of Bern. CONGRATULATIONS !

See at the bottom of the following page: www.unibe.ch/university/university_for_everyone/dies_academicus/dies_academicus_2017/index_eng.html

 

 

 

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