Highlighted Publication

First structure of an SLC16 family transporter homologue with bound substrate and inhibitor.

Please see our recent publication: Bosshart et al. (2019), Nature Commun.

The Fotiadis Lab

Want to learn about the Fotiadis Lab and its research ?

Please see our publication in International Innovation (2013).

Click here to download the PDF


Welcome to the website of the Fotiadis Lab

Structural biology of membrane proteins

We investigate the structure and supramolecular organization of membrane proteins using high-resolution microscopy techniques, i.e. transmission electron microscopy (TEM) and atomic force microscopy (AFM), and X-ray crystallography.

Schematic representation of our working strategies, see Meury et al. (2011), Biol. Chem.


Single particle analysis is used to determine the structure and oligomeric state of detergent-solubilized membrane proteins from projection images obtained by TEM.
Electron crystallography of 2D membrane protein crystals is applied to reveal the projection and 3D structure of membrane proteins embedded in the lipid membrane. To determine the topography and dynamics of membrane proteins, proteoliposomes and 2D crystals are imaged by AFM.

In 2006 we also started expanding to 3D crystallization and X-ray crystallography of membrane proteins.

Our mission

Our mission is to assess the structure and supramolecular organization of membrane proteins in the detergent-solubilized state and in their native environment, the lipid bilayer.   

Target proteins

Our target membrane proteins consist mainly of membrane transport proteins and receptors.

Latest Tweets from FotiadisLab @IBMM_UniBE

June 14, 2019:

First structure of an SLC16 solute carrier family transporter with bound L-lactate and inhibitor:

Thank you and congratulations Patrick, David and Sara - you did a great job !

February 25, 2019:

Volta phase plate cryo-EM: A first look at the structure of the heterodimeric human amino acid transporter 4F2hc-LAT2 under close to native conditions

Please see the latest publication from the FotiadisLab/NCCR TransCure:

February 21, 2019:

New publication of the FotiadisLab within the NCCR Molecular Systems Engineering:
Greetings to our collaborators in Basel ! 

December 3, 2018:

New Sinergia Project at the IBMM

The SNSF has granted a Sinergia Project to Dimitrios Fotiadis (UniBE) together with the laboratories of Philippe Plattet (UniBE) and Rainer Riedl (ZHAW) entitled “Morbillivirus cell entry machinery: mechanisms, structures and drug discovery”.

June 18, 2018:

New publication of the FotiadisLab within the NCCR TransCure:
Greetings to our collaborators in NYC !

December 6, 2017:

Hüseyin Ilgü from the FotiadisLab and NCCR TransCure receives the Dr. Lutz Zwillenberg-Prize for his excellent Ph.D. thesis at the Dies Academicus 2017 of the University of Bern. CONGRATULATIONS !

See at the bottom of the following page:




Our research is founded by