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Highlighted Publication

Crystal structures of wild-type AdiC in the presence and absence of the substrate agmatine at 2.6-Å and 2.2-Å resolution.

Please see our recent publication: Ilgü et al. (2016), Proc. Natl. Acad. Sci. USA

The Fotiadis Lab

Want to learn about the Fotiadis Lab and its research ?

Please see our publication in International Innovation (2013).

Click here to download the PDF

Eins->Zwei->Drei

Welcome to the website of the Fotiadis Lab

Structural biology of membrane proteins

We investigate the structure and supramolecular organization of membrane proteins using high-resolution microscopy techniques, i.e. transmission electron microscopy (TEM) and atomic force microscopy (AFM), and X-ray crystallography.

Schematic representation of our working strategies, see Meury et al. (2011), Biol. Chem.

Methods

Single particle analysis is used to determine the structure and oligomeric state of detergent-solubilized membrane proteins from projection images obtained by TEM.
Electron crystallography of 2D membrane protein crystals is applied to reveal the projection and 3D structure of membrane proteins embedded in the lipid membrane. To determine the topography and dynamics of membrane proteins, proteoliposomes and 2D crystals are imaged by AFM.

In 2006 we also started expanding to 3D crystallization and X-ray crystallography of membrane proteins.

Our mission

Our mission is to assess the structure and supramolecular organization of membrane proteins in the detergent-solubilized state and in their native environment, the lipid bilayer.   

Target proteins

Our target membrane proteins consist mainly of membrane transport proteins and receptors.

Latest Tweets from FotiadisLab @IBMM_UniBE

August 23, 2017:

First International Conference on Molecular Systems Engineering (MSE) organized by the NCCR MSE - see you there !

-> www.nccr-mse.ch

June 8, 2017:

Latest FotiadisLab publication in J. Struct. Biol.:

ncbi.nlm.nih.gov/pubmed/28522226

One step closer to the PTS IIC glucose transporter structure...

May 24, 2017:

A publication from a nice NCCR Molecular Systems Engineering collaboration in the prestigious journal Nano Letters:

www.ncbi.nlm.nih.gov/pubmed/28361535

May 19, 2017:

Join this Monday, May 22 the BVB/NCCR TransCure seminar by Dr. Thomas Stockner on neurotransmitter transporters !

www.dcb.unibe.ch/about_us/news_amp_events/seminars/biochemistry/index_eng.html

May 13, 2017:

Latest FotiadisLab publication in Photochemistry and Photobiology: onlinelibrary.wiley.com/doi/10.1111/php.12763/full

Nice collaboration with the MPI Dortmund !

 

Our research is founded by